Cancro da Cabeça e Pescoço
MULTI-MODALIDADE
The role of neck dissection (ND) after neoadjuvant chemotherapy (CT) with docetaxel, cisplatin and 5-fluorouracil (TPF) followed by concomitant chemoradiation (CR) with cisplatin for patients with locoregionally advanced squamous cell carcinomas of the head and neck (SCCHN)
I. Pires da Silva, J. Mouta, P. Winckler, D. Costa, E. Netto, J. Rosa Santos, M. Magalhães, T. Alexandre, I. Sargento, M. Ferreira, A. Moreira
P201|abstract 2818
The majority of SCCHN patients (2/3) present with advanced stages (III/IV). Although the standard treatment is cisplatin-based concomitant CR, some centers use induction CT with TPF prior to definitive locoregional therapy to improve response and survival. The clinical relevance of neck dissection after this regimen is still unclear. We present the results from our institution, including number of ND performed, pathological result and side effects from ND in this context.
Induction chemotherapy with docetaxel, cisplatin and fluorouracil in locally advanced oral cavity cancer
J.C. Pereira, C. Araújo, A. Moreira, M. Cassiano, J. Dinis, C. Ribeiro, A. Sousa, A. Ferreira, A. Mesquita, P.C. Martins, R. Capelo, M. Lima, D. Cunha, D. Brito, C. Sanches, J. Guimarães, J. Abreu de Sousa
P215|Abstract 2832
Background: Surgical excision is the mainstay of treatment for oral cavity cancers. Locally advanced oral cavity cancers (LAOCC) have a poor prognosis and surgical treatment in this setting usually implies severe mutilation and organ dysfunction. Induction chemotherapy doesn't have a well established role in these patients but it might be beneficial by reducing tumour size and allowing definitive surgery with preservation of organ function and improvement of the overall survival.
16h45-18h45 | Hall C
Ciência Básica/Investigação Translacional
DANOS E REPARAÇÃO DO ADN
The intricate interplay between MSI and polymorphisms of DNA repair enzymes in gastric cancer H.pylori-associated
I. Silva-Fernandes, D. Costa, E. Pereira, J. Carvalho, M. Ribeiro, S.H. Rabenhorst
P014|Abstract 129
Background: Gastric cancer (GC) is the fourth most common cancer globally, and Helicobacter pylori is a well-established risk factor, mainly for intestinal gastric cancer (IGC). The inflammatory process is one of the pathways leading to gastric carcinogenic and H. pylori strains carrying virulence genes can trigger this in a chronic way. As a consequence, DNA damage can occur and efficient repair systems are required to maintain genomic integrity. However, polymorphisms in key enzymes that influence their efficiency could be relevant for genome integrity. Genomic instability is a marker for GC and can be inferred by microsatellite instability (MSI) using loci that are stable in the population. There is a lack of studies linking MSI and polymorphisms in DNA repair enzymes. Also, the presence of the H. pylori genes has been hardly explored. Accordingly, this study aimed to examine, in 118 cases, the influence of polymorphisms in key enzymes of the repair system on DNA repair using BAT-25, BAT-26, D17S250 and D2S123 as markers for MSI. In addition, H. pylori virulence and the histological subtypes were considered in these analyses.
MULTI-MODALIDADE
Impact of lymph node ratio in locally advanced rectal cancer
A. Freire Coelho, S. Póvoa, C. Rey, C. Sarmento, M. Marques, P. Silva, M. Damasceno
P040|Abstract
The number of metastized lymph nodes (LN) is one of the most important prognostic factors in colo-rectal cancer. According to TNM staging system, a minimum of 12 LN must be excised. In locally advanced rectal cancer (LARC) that went through neoadjuvant chemoradiotherapy (N-CRth), often this goal is not accomplished. A promising value in the prognosis of LARC has been shown for the LN ratio (LNR: Metastized LN/Resected LN). Our aim was to evaluate the impact of LNR on the survival outcomes of patients with LARC who underwent N-CRth and surgery.
TOXICOLOGIA
Cisplatin in day hospital
D. Romeira, D. Cardoso, M. Miguens, M. Malheiro, C. Rodrigues, M. Pinto, C. Carvalho, H. Miranda, A. Martins
P070|Abstract 359
Background: Cisplatin is an anti-neoplastic drug used in the treatment of various types of solid tumors (head and neck, ovarian, lung, breast). The profile of toxicity includes: myelotoxicity, neurotoxicity, gastrotoxicity and ototoxicity. The nefrotoxicity is, however, the most relevante adverse effect, limiting her use. The most common presentation is as acute kidney injury (AKI), which occurs in 20–30% of patients. The estimated creatinine clearance (CrCl) measured by different equations (Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD)), based on creatinine serum concentration, is sufficient and usually with the same accuracy.
